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Those formulations can now be designed to load multiple agents and be multi-functional ( Figure 3 ), including but not limited to pH-specific drug-releasing (115, 124), in vivo drug tracing (152, 155), and tumor hypoxia relief (106)

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Furthermore, silibinin's ability to regulate mitophagy and ferroptosis enhances cellular resilience and modulates oxidative stress, further contributing to its anti-cancer effects