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For example, neuroinflammation causes the induction of a neurotoxic reactive subtype, termed A1-type astrocytes, by microglial cytokine release (Liddelow et al., 2017), which can kill oligodendrocytes and neurons by secreting toxic lipids

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Acetaldehyde is toxic, even more so than alcohol, and our bodies have to use large amounts of glutathione (our most powerful natural antioxidant) to clear the stuff