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Research suggests NNMT inhibition might: 1) Increase NAD+ availability by reducing nicotinamide methylation, and 2) Affect methylation balance by altering SAM utilization

Lean C57BL/6J mice and genetically obese (ob/ob) mice, all 12 weeks old, were divided into three treatment groups including: saline control, AOD9604 at a dose of 250 g/kg/day, and hGH at a dose of 1 mg/kg/day, with each group consisting of six mice