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Unusual incident reports (UIRs) are a formal mechanism for documenting clinically significant medication errors and near misses

303,304 Van Es et al 303 showed a statistically significant increase in ejection fraction among 13 patients (mean, 48.6% versus 42.4%) after 3 months of L-carnitine therapy (1 g IV after each hemodialysis session)

This pathway has been found to have a significant role in the normal masculinization of the male fetus (see 13) and abnormal virilization of the female fetus in cases of congenital adrenal hyperplasia resulting from mutations in the enzyme P450 oxidoreductase (14)

Covariates To control for potential confounding effects, we included the following covariates: age, gender, marital status, body mass index, annual family income, race/ethnicity, educational level, smoking status, drinking status, caffeine intake, diabetes, and hypertension