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Sixth, further detailed characterization of the mechanisms that modify the effect of KD-induced neuroprotection is needed, including the role of expression levels of relevant transcription factors, BHB receptors and MCT transporters, local ketone body concentration, gut microbiome species and mitochondrial density and function, all of which could contribute to variation in the response to KD

Therefore, BMD alone is insufficient for fully understanding bone health, particularly regarding bone microarchitecture

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To detect potential sources of heterogeneity, subgroup analyses were performed according to the predefined variables, including duration of the intervention, NAC dosage, study location and the type of control