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For instance, Jonny et al (47) conducted a systematic review on the therapeutic potential of tolDCs in autoimmune diseases, including systemic lupus erythematosus, demonstrating that the induction of tolDCs in vitro can effectively modulate T-cell responses and promote antigen-specific immune tolerance

His work was pivotal to link the essential trace element selenium to metabolic processes, which led the Food and Drug Administration (FDA) to approve selenium supplementation for humans in 1980, and stimulated selenium biochemistry in general

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