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The consequence of this role is that the ER is a net consumer of GSH and the GSSG has to be recycled by an unidentified mechanism

Through 13 C 5 -glutamine labeling experiments, they found that these prostate cancer cells also exhibited a greater reliance on glutamine following exosome uptake, with increased levels of 1 3 C-labeled m + 5 -KG and m + 5 glutamate indicative of reductive glutamine metabolism for anaplerosis into the TCA cycle