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These factors contribute to abnormal microglial activation and the disruption of endothelial tight junctions, ultimately compromising the integrity of the neurovascular unit [33]

Because it is present mainly in extracellular fluids like the plasma it was nominated estracellular SOD (ECSID)

The natural flavonoid orientin improves high-glucose-induced endothelial ferroptosis and cellular functions through the Nrf2/GPX4 pathway, accelerating healing of full-thickness skin defects in diabetic mice [84]

doi: 10.3389/fimmu.2018.02658 Received 03 September 2018 Accepted 29 October 2018 Published 16 November 2018 Volume 9 - 2018 Edited by Jos Carlos Crispn, Instituto Nacional de Ciencias Mdicas y Nutricin Salvador Zubirn (INCMNSZ), Mexico Reviewed by Pier Luigi Meroni, Istituto Auxologico Italiano (IRCCS), Italy