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As oligodendrocytes are the main sites of iron storage in the brain 24 , the stimulation of FPN1-mediated iron export via decreased hepcidin is expected to increase free extracellular iron, which may, in turn, result in oxidative stress in the SN in PD patients

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For instance, single-cell RNA sequencing of microglia in germ-free vs colonized mice with neurodegenerative pathology can pinpoint microglial genes influenced by the microbiome