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Vitamin D, produced locally by monocytes, results in a shift in the immune status from proinflammatory to tolerogenic and regulates CD4 + T-cell responses by suppressing T helper (Th1) cell function and decreasing proinflammatory cytokines production, as illustrated in Fig

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A clinical trial evaluating the impact of EGCG on the length of recombinant tissue plasminogen activator therapy window in stroke patients found that patients with delayed onset-to-treatment time had better treatment outcomes after receiving EGCG

10.1016/j.lfs.2022.121127 314 ZhangX.WuS.GuoC.GuoK.HuZ.PengJ.et al (2022c)