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Another typical feature of PCOS is chronic anovulation and the standard approach for the treatment of women with anovulation infertility consists of administration of clomiphene citrate to induce ovulation, however, some women fail to ovulate despite taking increasing doses of clomiphene citrate and, therefore, defined as clomiphene citrate-resistant PCOS

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The standardized mean difference (SMD) and 95% confidence interval (CI) used to compare the effect size ( 2 + SD final 2 ) (2 0.5 SD baseline SD final)] ( 2 estimation ( 2 values less than 25% as low heterogeneity, values between 25 and 50% as moderate heterogeneity, and values exceeding 50% as high heterogeneity