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CD45 phosphatase inhibits STAT3 transcription factor activity in myeloid cells and promotes tumor-associated macrophage differentiation

Along these lines, it has been reported that patients with IBD display an activated mucosal immune system, with high infiltration of plasma cells, neutrophils and macrophages, accompanied by overexpression of pro-inflammatory cytokines and various chemokines that promote the recruitment of inflammatory cells (64)

Nature 504 , 446450 (2013)

Mitochondrial dysfunction in rheumatoid arthritis: A comprehensive analysis by integrating gene expression, protein-protein interactions and gene ontology data