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Some people may require more frequent doses to maintain levels of B12 or amino acids, while others may find that less frequent injections are sufficient

The resulting stock solution can then be stored at 28C for subsequent use across multiple experimental sessions, with the benzyl alcohol content maintaining sterility throughout

Progressive weakness, worsening balance problems, or new neurological symptoms require prompt assessment, as these may indicate inadequate treatment or concurrent conditions

Notably, controlled fluid flow introduces sustained perfusion and physiologically relevant shear forces, both of which modulate cellular behaviour and allow for a more accurate assessment of nanoparticle transport, distribution and cellular uptake than static in vitro models [175, 176]