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Gut colonization of the newborn begins with facultative anaerobes such as enterobacteria and streptococci and continues with anaerobic genera, including Bifidobacterium , Bacteroides , and Clostridium [110,111]

Type II collagen, predominantly found in cartilaginous structures, provides a resilient framework that enables these tissues to withstand compressive forces [52], also known as reticular fiber, which is present in connective tissues, contributing to their integrity through its flexible nature [53, 54]

Lapin and Ebels 1976 paper was one of the first to outline these properties, and subsequent studies have provided further clarification on the molecular basis for melatonins efficient tissue penetration and cellular accessibility (Lapin and Ebels 1976)