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While externally produced short-lived reactive species such as hydroxyl radicals, superoxide anion radical, and singlet oxygen all decay much too rapidly to enter the human body, photo-oxidation results in a variety of longer lived potentially active compounds, including peroxides, which once ingested or inhaled could conceivably have sufficiently long lifetimes in vivo to cause adverse effects

These observations suggest VIP signaling may stabilize gut-brain communication during exercise and potentially aid GI tolerance, mood, and training adherence 102

ROS induces several cellular effects, including cell cycle progression, apoptosis, DNA damage, senescence, and neurodegeneration

Other providers require a minimum age of 14 and a minimum weight of 100 pounds alongside parental approval