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GLUT3, Glucose transporter 3

Tissue glutathione levels tend to decline with age, a phenomenon that may reflect declining function of Nrf2-mediated induction of phase 2 enzymes (including glutamate cysteine ligase), as well as lower tissue levels of cysteine and glycine.9,18-20 Phase 2 inducer nutraceuticals such as lipoic acid can be used to compensate for this decline in Nrf2 activity.18 An epidemiologic analysis found that while relatively low protein intakes predicted lower subsequent mortality in subjects 65 years

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Studies have found that indole can alter the composition of gut microbiota and increase gene expression of TJPs and mucins between epithelial cells, indicating enhanced intestinal epithelial barrier (Shimada et al., 2013)