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297,298 Microvascular contributions Microvascular dysfunction plays a significant role in the pathogenesis of DPN

Cushingoid features, growth retardation, increased risk for infections), and suppression of the hypothalamic-pituitary-adrenal (HPA) axis, which can result in an adrenal crisis if doses are not carefully tapered after a patient has been on systemic steroids for more than 15 days (Aljebab et al, 2017)