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some microbially modified bile acids (like iso-deoxycholic acid) can cross into the brain and have been shown to modulate microglial activity and cholesterol metabolism in neurons [80]

Elementary Flux Mode Analysis (EFMA) As our culture medium mimics the wine composition, it contains different carbon sources and thus it is difficult to elucidate which substrate is being used to synthesize a particular product

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A deeper understanding of these interconnected metabolic networks clarifies the critical role of ferroptosis in OA progression and lays a robust foundation for integrated therapeutic strategies targeting both metabolic reprogramming and ferroptosis