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the endosomolytic component may contain a chemical group (e.g., an amino acid) which will undergo a change in charge or protonation in response to a change in pH

Although several studies have supported the view that CX36 may also be involved in epileptogenesis, there is still an ongoing controversy associated with the alterations of CX36 at different developmental stages of human and animal models of epileptogenesis (Wu et al., 2018)

doi: 10.1097/HS9.0000000000000165

In summary, Alzheimers disease is a complex, multifactorial disorder in which ferroptosis, driven by iron overload, lipid peroxidation, and redox imbalance, plays a pivotal role