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Based on the above discussion, this paper proposes a translational roadmap from the current understanding to future clinical practice, with the core shift from population-based medicine to precision microbiome and immunometabolic editing. Firstly, a multi-dimensional biomarker typing system should be constructed

Taken together, our work demonstrated that ACE induces ferroptosis in tumor cells through a dual mechanism: on the one hand, ACE enhances intracellular Fe 2+ -induced ferroptosis by directly binding and degrading PCBP 1/2, and on the other hand, ACE induces GPX4 ubiquitination and degradation by directly binding to GPX4

IV therapy plays a key role in recovery by delivering specific nutrients that target post-surgical challenges