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The American Diabetes Association and American College of Gastroenterology both specify that GLP-1 agonist monotherapy (one medication from this class) represents the evidence-based standard of care, not combination therapy with multiple agents from the same drug family

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Despite the development of numerous drugs targeting specific pathological features of AD, such as amyloid-beta (A) deposition and neurofibrillary tangles, very few have been approved in the past 20 years, underscoring the limitations of single-target therapeutic approaches