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10.3892/mmr.2015.3336 126 WangQ

Biochem Biophys Res Commun (2020) 533(4):10837

In vivo studies employing PPAR-null mice and PPAR-humanized mouse carcinogenicity tests have yielded conflicting results, with some evidence of DEHP hepatocarcinogenesis in both genotypes

The safety and immunogenicity (type I IFN dependent responses) as well as the delivery efficacy of loaded immune adjuvants [poly(I:C)) in a proposed biomaterial matrix were further validated in canine veterinary models with cancer [121, 122]