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The IV's hydration also plumps skin, making fine lines less noticeable

Pegaptanib sodium was the first anti-VEGF drug approved by the FDA to treat wet AMD, but this drug has largely been replaced with improved alternatives like bevacizumab, ranibizumab, and aflibercept due to better results shown in various trials

However, the flat surface of Ras proteins that precludes the binding of small-molecule inhibitors has hindered the development of effective drugs for cancer treatment, since the affinity of the reported small compounds is in the micromolar range 45,46,47,48 and below the required value for clinical applications 49

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