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Under-methylation Under-methylation occurs when the synthesis of SAM in the methionine cycle is disturbed

Corsini EM, Datar SS, Mitchell KG, Zhou N, Hofstetter WL, Mehran RJ, Rajaram R, Rice DC, Roth JA, Sepesi B, Swisher SG , Vaporciyan AA, Walsh GL, Blackmon SH, Loree JM, Morris VK, Antonoff MB

61 In our recent reports, the activation of GSK3 is also increased in the sorted astrocytes from the MDD-related stress-treated mice model and MDD clinic patients plasma

Novel noninvasive physical approaches with few toxic adverse effects have been used to eliminate GBM cells in translational studies, including photothermal therapy(PTT) (120, 124), photodynamic therapy(PDT) (140), and sonodynamic therapy(SDT) (116)