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Administration of D-limonene in HFD fed young male wistar rats at the dose of 80 mg/L drinking water shows increases in blood pressure, heart rate, fasting blood glucose, plasma insulin, hepatic marker enzymes, and hepatic phase I enzyme activities along with that it also decreases the circulatory nonenzymic antioxidant concentrations and hepatic phase II enzyme activities [144]

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Intriguingly, these mechanisms were likewise found in the development of SG fibrosis

A 2023 safety review of probiotics highlighted theoretical and documented risks, including bacteremia or fungemia in high-risk patients, immune dysregulation, and the potential for horizontal transfer of antimicrobial resistance or virulence genes within the gut ecosystem (525)