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As an alternative to conventional whole-cell approaches, proteomic studies to elucidate CDDP resistance have been performed on enriched subcellular compartments (e.g., nuclei, mitochondria), 258, 259, 260 purified components known to participate in CDDP-elicited signaling pathways (e.g., immobilized CDDP, Y-box binding protein 1), 149, 261 as well as on serum samples from cancer patients

L-glutathione is a tripeptide, which is a fancy way of saying it is made up of three specific amino acids: cysteine , glutamic acid , and glycine

Inhibiting this pathway holds promise as a hopeful therapeutic approach for HCC (10)

Antitumor activity of Daraxonrasib in subcutaneous xenograft models of A) MIA PaCa-2