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While the pathological and clinical presentations of neurodegenerative diseases vary, they share common features including specific pathological alterations within distinct brain regions and the degeneration of various neuronal subtypes

parenteral as used herein includes subcutaneous, intracutaneous, intravenous, intramuscular, intra-articular, intrasynovial, intrasternal, intrathecal, intralesional and intracranial injection or infusion techniques

VS has two significant advantages over HTS: first, the number of compounds that can be screened far exceeds that of experimental methods