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R01 ES007912-11)

Commonly reported reactions in human studies are generally mild to moderate gastrointestinal issues, including nausea, vomiting, and diarrhea

[20,21] Overview of Cancer Therapeutic Agents Chemotherapy agents can be divided into several categories: alkylating agents (e.g., cyclophosphamide, ifosfamide), antibiotics which affect nucleic acids (e.g., doxorubicin, bleomycin), platinum compounds (e.g., cisplatin), mitotic inhibitors (e.g., vincristine), antimetabolites (e.g., 5-fluorouracil), camptothecin derivatives (e.g., topotecan), biological response modifiers (e.g., interferon), and hormone therapies (e.g., tamoxifen).The agents most noted for creating cellular damage by initiating free radical oxidants are the alkylating agents, the tumor antibiotics, and the platinum compounds

The amino acid residue ASP 810 was the key amino acid for the binding of the c-Kit protein with inhibitors