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Description

Int J Mol Sci 27(5):2497

This higher reactivity may allow more (protein) off-target thiol interactions to take place causing a decrease in the effective cellular concentration compared to more rigid and specific cyclic Michael acceptors

The nanoassembly is formed by self-assembly from three glutathione (GSH)-responsive polymers, including poly(-valerolactone) (PVL) as a hydrophobic component and 3,3-dithiodipropionic acid (DA) as a cleavable linker to hydrophilic components