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FIGURE 1 As a free radical, NO could also react with various intracellular/extracellular targets and form a series of molecules, such as NO radicals (NO - ), nitrosonium ions (NO + ), peroxynitrite (ONOO - ), S -nitrosothiols (SNOs), higher oxides of nitrogen (NO x ) and dinitrosyl-iron complexes among others, collectively these NO derivatives are termed reactive nitrogen species (RNS

Although many studies using activation paradigms noted an increased amygdala response in mania, resting-state imaging did not detect increased amygdala activity compared with healthy controls (105, 106, 136)

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