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Ishikawa F, Kaneko E, Sugimoto T et al (2014) A mitochondrial thioredoxin-sensitive mechanism regulates TGF--mediated gene expression associated with epithelial-mesenchymal transition

Current therapies based on MEK, BRAF and CDK4/6 inhibitors tend to induce resistance by activating OXPHOS and fatty acid oxidation, thus reducing the tumour mass but increasing the risk of relapse [56]