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A clinical review of sUA data from the 0.2, 0.4, and 0.8 mg/kg cohorts revealed that there was no further extension in the duration of uric acid lowering beyond the 0.2 mg/kg pegadricase dose, thus a decision was made to prematurely stop enrollment of subjects in the 1.2 mg/kg group

p38-MAPK-mediated translation regulation during early blastocyst development is required for primitive endoderm differentiation in mice

Bevacizumab therapy reportedly promotes PlGF, VEGF-C, and VEGF-D production which in turn activates VEGFR-1 and VEGFR-2 and leads to bevacizumab resistance

Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity