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(2018), neurodegeneration-associated molecular patterns (NAMPs) was proposed as endogenous danger signals commonly present in various CNS conditions, which are recognized by a battery of specific receptors constitutively expressed on microglia and trigger their transition into DAM (Figure 3, Table 1), whose primary function is to contain and remove the damage

This suggests that the C159, Y296 and H571 residues influence the initial redox equilibrium between the flavin and the NADPH

Consequently, attenuating the expression of GGT5 would impede GSH metabolism and enhance anti-tumor capabilities

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