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Klimas and Gordon Broderick used the a Consortium Award from the Congressionally Directed Medical Research Programs (CDMRP) to develop an animal model and to use exercise, massive data gathering efforts and computational biology to attempt to understand the processes at work in GWI and identify potential treatment targets

Tokyo: Labour and Welfare Bureau Ministry of Health (2006)

Physiologically, it serves as an essential cofactor in the conversion of methylmalonyl-CoA to succinyl-CoAa substrate for the tricarboxylic acid cycleand plays fundamental roles in DNA and protein synthesis, methylation cycles, and folic acid metabolism (73)