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The ability to replicate, in the laboratory, the early stages of human brain development to understand how mitochondrial dysfunction affects its normal development represents a great hope for researchers and patients of this group of rare diseases

19 The marked impact of SAM supplementation is prevention of mitochondrial DNA damage and mitoribosome dissociation

Adenosine monophosphateactivated protein kinase signaling pathway AMPK-mediated BECN1 phosphorylation can promote ferroptosis by blocking system Xc activity (Song et al., 2018)

Several reproducible glioma models in pigs are evolving as preclinical large-animal models (326329)