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The hypocretin/orexin neuropeptides are essential for the maintenance of wakefulness and the suppression of REM sleep, and zebrafish possess a functional hcrt-pineal gland circuit, connecting the hcrt and melatonin systems together in sleep consolidation (Appelbaum et al

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A study found that feeding rats EGCG before or after TBI prevented the production of free radicals, preventing neuronal degeneration and apoptotic death