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Gln depletion treatment activates FADD and caspase-8-dependent apoptosis involving pro-apoptotic TNF-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) in tumour cells, while metabolic stress induced by glutamine deprivation leads to the downregulation of the GCN2-non-dependent FLICE-inhibitory protein (FLIP), which promotes caspase-8 activation and apoptosis [55]

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doi: 10.1001/archneur.59.10.1541 207 The Parkinson Study Group QE3 InvestigatorsBealMFOakesDShoulsonIHenchcliffeCGalpernWRet al

doi: 10.7150/jca.89120 69 KryczkaJKryczkaJJanczewskiGajdaAFrczykABoncelaJet al