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"Fatty acid oxidation and carnitine palmitoyltransferase I: emerging therapeutic targets in cancer." Cell death & disease 7.5 (2016): e2226-e2226.

doi: 10.7570/jomes23054

Given that the majority of the DNA methylation sites (CpGs) investigated in these studies were in promoter regions, and given the association of promoter region DNA hypermethylation with decreased gene expression, this supports an important role for DNA methylation in silencing cell cycle and proliferation genes and in activating myelin genes, thus enabling OPCs to leave their proliferative state and differentiate into myelinating OLGs