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They are running an uncontrolled experiment on their own tissue

Dopamine plays a crucial role in the transition from nonrapid eye movement (NREM) sleep to rapid eye movement (REM) sleep through a transient increase in the basolateral amygdala (BLA), acting on D2 dopamine receptors to initiate the NREM-to-REM shift

10.3389/fimmu.2019.02067 445 UhdeM.IndartA

Because the full dose enters circulation immediately, clients typically experience noticeable effects within the first few sessions, rather than waiting weeks or months for gradual accumulation