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It is also meant to guard against attributions of causality to biologically implausible statistical associations that might result from studies that have not adequately accounted for important variables

Defects in the BCAA metabolism-related gene, protein phosphatase Mg 2+ /Mn 2+ -dependent 1 K (PPM1K), can disrupt energy metabolism homeostasis within the follicular microenvironment, potentially leading to PCOS-like phenotypes 15