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revealed that allogenic MSCs suppressed pathogenic Th1 cell expansion, promoted Tregs induction in peripheral blood of AA patients, and significantly blocked the activation of the JAK/STAT signaling pathway, achieving effects comparable to those of ruxolitinib [60]

On the other hand, beneficial metabolites such as butyrate can activate cellular mechanisms for protein clearance: butyrate readily crosses the BBB and can inhibit histone deacetylases, thereby activating gene expression programs that enhance autophagy and reduce toxic protein aggregates [55]

As with any medication, side effects are possible

Mini-Mental State Examination (MMSE), developed by Folstein, Folstein, and McHugh [511], takes advantage of the impairment in memory and executive functions