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In AP, however, this finely tuned system shifts toward pathological oxidative stress, with disturbed redox homeostasis promoting excessive ROS production and propagation of organellar injury in PACs ( Mitochondria are a major intracellular ROS source in AP, particularly at complexes I and III of the ETC

Marshall DA, Grazziotin LR, Regier DA, Wordsworth S, Buchanan J, Phillips K, et al

10.1161/HYPERTENSIONAHA.120.1654733356394 113 Wang L, Mesa-Eguiagaray I, Campbell H, et al

Stable gastric pentadecapeptide BPC 157, in clinical trials as a therapy for inflammatory bowel disease (PL14736), is effective in the healing of colocutaneous fistulas in rats: role of the nitric oxide-system