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(Esteghamati et al., 2014) documented a significantly relationship among elevated Hcy levels and major manifestations of MetS, including impaired glucose tolerance (IGT), abdominal obesity, elevated blood pressure, and hypertriglyceridemia

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Oral administration faces hepatic first-pass metabolism, reducing bioavailability to approximately 4050% of subcutaneous routes, but offers convenience for longer-term studies where daily injections create compliance challenges