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Management of Psychiatric Disorders in patients with hepatic and gastrointestinal diseases

Excessive ROS serve not only as a direct agent causing damage to biological macromolecules but also as a potent second messenger that activates key pro-inflammatory signaling pathways, such as NF-B and MAPK, through the oxidative modification of essential signaling proteins (62)

The following trials of antioxidants need then to be rigorous, identifying not only any positive patient outcomes, but also the underlying mechanism, and of course any deleterious outcome

doi: 10.1016/j.phymed.2022.153930 99 AmbookenBAbdulsalamSAsokanNet al