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For example, abnormal iron accumulation in the retina promotes the development of age-related maculopathy, and iron accumulation in the intravitreal or intravitreal subretinal effusion is closely related to poor visual recovery after retinal detachment [14, 16]

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Additional complexity, and in accordance with IGF-1 secretion patterns, appeared when researchers found that IRS-1 was found more active in post-prandial states contrary to IRS-2 in fasting states [121]