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Additional work has to be done to improve treatments that deal with the colonization and recolonization of the periodontal pocket by microbes to reduce antibiotic use and the cumulative negative effects of recurrent therapy [94]

Moreover, the GSK3-Nrf2 signaling pathway could obstruct ferroptosis via its antioxidant potential (Huang et al., 2022a)

Also, the term synbiotics is defined as a mixture comprising live microorganisms and substrate(s) selectively utilized by host microorganisms that confers a health benefit on the host [305]