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Although effective in vitro, it displayed weak activity in vivo and could not be widely applied

Protein oxidative damage in the stratum corneum: Evidence for a link between environmental oxidants and the changing prevalence and nature of atopic dermatitis in Japan

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As neurosteroids, DHEA and DHEAS can bind directly to neurotransmitter receptors, and have been found to modulate neural activity by acting as noncompetitive antagonists at GABAA receptors, reducing inhibitory neurotransmission, and as positive allosteric modulators at NMDA receptors, enhancing excitatory signaling, and facilitating dendritic growth, axonal elongation, and synaptic plasticity in response to environmental stimuli (, )