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Eder, J

PINK1 suppresses activation of innate and adaptive immune responses that are triggered by mitochondrial stress or bacterial infection 26,27

Second, the underlying molecular processes behind the occurrence of distant metastasis, dormancy, and late-stage disease recurrence, especially in hormone receptor-positive breast cancer, are not fully understood, making it difficult to develop efficient metastasis-preventive therapies (327)

Eric Topol (31:14): I think that's a vital point you're making because the success of a clinical trial here in a clinical syndrome that is mosaic with lots of different types of pathways