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Chemotherapy has been described to deplete the ovarian reserve through both direct toxicity to oocytes (Nguyen et al, 2019), granulosa cell apoptosis (Lopes et al, 2020

Thus, metformin may be beneficial by providing mild inhibition of complex I, because the reduced ATP/ADP ratio activates the AMPK signaling pathway, thereby promoting autophagy-mediated degradation of misfolded proteins and dysfunctional organelles [157]

The affected joint is hot, swollen and so tender that even the weight of the sheet on it may seem intolerable

A variety of natural and synthetic compounds have been identified as activators, and some of their mechanisms of action have been partially elucidated