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1 Introduction Psoriasis (PSO) is a chronic immune-mediated inflammatory disease that affects approximately 2-4% of the population worldwide ( The interaction between the gut microbiome and inflammatory skin diseases is mediated by a dysfunctional gut microbiome, a disrupted gut barrier, increased inflammatory mediators, and metabolites produced by microorganisms ( B

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**Anti-Inflammatory Properties** Chronic knee pain often stems from inflammation within the joint

Thus, high DHA levels may induce brain toxicity and haemolysis via mechanisms similar to those described by Yun et al